Fecal Microbiota Transplant and Its Evolving Medical Uses

It's been a while since I posted about my son "Jake".  For those who haven't read his story, here is the link   http://www.fecalmicrobiotatransplant.com/2013/07/crohns-disease-fmt.html  . He has been off medication (Imuran) for nine months now and looks and feels well.  Unfortunately his cousin who was his donor became unsuitable to donate in mid August due to picking up a parasite, so Jake has gone since then without any FMT . Today he had a colonoscopy and endoscopy and we were thrilled with the news.  There is no sign of Crohn's Disease anywhere - not in his intestines, not in his terminal ileum and not in his duodenum!!! In fact, Professor Borody said there was no scarring or ulceration or any indication that the disease had ever existed.  It was all perfect, healthy and inflammation-free.  When he was first diagnosed with Crohn's three years ago it was very widespread.  I am sure that anyone ...

This story comes from a mother who posted as a visitor on http://thepowerofpoo.blogspot.com.au/ - it's a very powerful story showing the tremendous results that FMT can give to a IBD sufferer (a child). It's definitely worth reading! Kathy's Success Story "Hi, I’m Kathy, mom to a nine-year-old girl diagnosed with Ulcerative Colitis in January 2012 and successfully treated with FMT. I don't want to know where we would be now if we hadn't tried it, or if it hadn’t worked. We went through seven months of hell trying to get her better before we started FMT. Here’s our story: E's symptoms appeared out-of-the blue. On Christmas Eve 2011, she called me into the bathroom to look at her wipe, which had some blood on it. Over the next few days, we noticed that her stool, though completely formed, had some visible blood coating the outside of it. I didn't make too much of it, which is surprising since I tend to be a bit of an alarmist when anyt...

The results of a randomized controlled study has been published in the New England Journal of Medicine this week which showed a 94% cure rate for clostridium difficile as opposed to 31% of patients taking the antibiotic vancomycin. The study was stopped prematurely becase the results were so outstanding for those who were given fecal transplant that it was considered to be unethical not to offer the treatment to all patients participating in the study. Read more below courtesy of the New England Journal.nbsp;  Here is a link to the study: Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile — NEJM and a link to the editorial written by Ciarán P. Kelly, M.D. Fecal Microbiota Transplantation — An Old Therapy Comes of Age — NEJM "Fecal Microbiota Transplantation — An Old Therapy Comes of Age Ciarán P. Kelly, M.D. January 16, 2013 DOI: 10.1056/NEJMe1214816 In 1958, doctors in Denver administered feces by enema to their patients with fulminant, life-...

Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy   Borody TJ, Warren EF, Leis S, Surace R, Ashman O.   Source   Centre for Digestive Diseases, 144 Great North Rd, Five Dock NSW 2046, Australia.   Abstract   Background   Although the etiology of idiopathic ulcerative colitis (UC) remains poorly understood, the intestinal flora is suspected to play an important role. Specific, consistent abnormalities in flora composition peculiar to UC have not yet been described, however Clostridium difficile colitis has been cured by the infusion of human fecal flora into the colon. This approach may also be applicable to the treatment of UC on the basis of restoration of flora imbalances.   Goal     To observe the clinical, colonoscopic and histologic effects of human probiotic infusions (HPI) in 6 selected patients with UC.   Case Reports   Six patients (3 men and 3 women aged 25-53 years) with...