Fecal Microbiota Transplant and Its Evolving Medical Uses

The excerpt of six case reports listed below come from the following medical publication.  Treatment of ulcerative colitis using fecal bacteriotherapy . These are examples of long term remission achieved by using fecal microbiota transplants to treat Ulcerative Colitis.  The report was published in 2003 - if you are interested in reading the report in more detail, please click the following link which will open up a new window at the site for the Centre For Digestive Diseases. Please note that HP in the case studies refers to "human probiotics" (or fecal microbiota transplantation) Treatment of ulcerative colitis using fecal bacteriotherapy. TJ Borody, EF Warren, S Leis, R Surace, O Ashman. J Clin Gastroenterol 2003; 37(1): 42-7. Patient 1 A 25-year-old man presented with a 6-year history of UC. He had experienced frequent blood in stools, diarrhea (6–7 motions per day), abdomin...

We are compiling a list of doctors and hospitals around the world who have performed fecal microbiota transplants - the list will grow as more doctors start to use this procedure on their ailing patients. We would love your help in compiling this list, so a comment with a name of a doctor/physician/medical professional and any information you can give would be very much appreciated! Please don't try this procedure without qualified medical guidance and advice. It is essential that fecal doners be screened for various diseases including some which are contageous. This is why a list of doctors who are familiar with the procedure is important, so that those of you who feel fecal microbiota transplantation could be beneficial to you can seek out appropriate medical advice. Doctors from around the world are listed below: Australia Professor Thomas Borody , Centre For Digestive Diseases Five Dock, Sydney USA Dr Lawrence J Brandt Montefi...

According to an article in the Sydney Morning Herald , stool transplants (fecal microbiota transplantation) are being used increasingly in the USA to successfully combat the deadly C.diff.  Reminds me of how the evolution of fungi into penicillin has saved the lives of so many since it's introduction.  Antibiotics are powerful in their ability to kill bacteria, but the problem is that friendly bacteria are also killed.  Fecal transplant appears to restore the normal balance.  One wonders if down the track fecal transplant will be used in some modified way to negate these harmful effects of antibiotics. "Drugmakers racing to develop medicines and vaccines to combat a germ that ravages the gut and kills thousands have a new challenger: the human stool. For patients hit hardest by the bacterium Clostridium difficile, getting a "stool transplant" could become a standard treatment within just a few years. Just as blood banks and sperm banks are now commonpla...

TITLE: Fecal Microbiota Transplantation (FMT) in Multiple Sclerosis (MS) AUTHORS/INSTITUTIONS : T.J. Borody, S.M. Leis, J.L. Campbell, M. Torres, A. Nowak, , Centre for Digestive Diseases, Five Dock, New South Wales, AUSTRALIA; ABSTRACT BODY: Purpose: Recent evidence implicates the GI microbiota in the progression of neurological diseases such as Parkinsons Disease 1, Multiple Sclerosis and Myasthenia Gravis 2. We report three patients with MS diagnoses who achieved durable symptom reversal with FMT for constipation. Methods: Case study observations on three MS cases   Results: Case 1: A 30 yr old male with constipation, vertigo and impaired concentration and a concomitant history of MS and trigeminal neuralgia. Neurological symptoms included severe leg weakness and he required a wheelchair and an indwelling urinary catheter. Previous failed treatments included Mexiletine, Tryptanol and 9-interferon. The patient underwent 5 FMT i...

Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy   Borody TJ, Warren EF, Leis S, Surace R, Ashman O.   Source   Centre for Digestive Diseases, 144 Great North Rd, Five Dock NSW 2046, Australia.   Abstract   Background   Although the etiology of idiopathic ulcerative colitis (UC) remains poorly understood, the intestinal flora is suspected to play an important role. Specific, consistent abnormalities in flora composition peculiar to UC have not yet been described, however Clostridium difficile colitis has been cured by the infusion of human fecal flora into the colon. This approach may also be applicable to the treatment of UC on the basis of restoration of flora imbalances.   Goal     To observe the clinical, colonoscopic and histologic effects of human probiotic infusions (HPI) in 6 selected patients with UC.   Case Reports   Six patients (3 men and 3 women aged 25-53 years) with...

Professor Tom Borody, on ABC TV Australia, Catalyst, Thursday, 14 July 2011 talks about Fecal Microbiota Transplantation (FMT) also known as "human probiotic infusion" for treatment of clostridium difficlile (c-diff).  He is the pioneer and leading world expert on FMT. Please Click This Link To Leave A Comment!

In order to understand why a person would have a Fecal Microbiota Transplant, we first need to understand the incredible history of Fecal Microbiota Transplants. In 1958, Chief of Surgery at Denver General Hospital, Dr Ben Eiseman, reported in the Journal of Clinical Gastroenterology of four patients who were cured of pseudomembraneous colitis.  Enemas containing feces from healthy colons successfully replenished good digestive bacteria.  Pseudomenbranous is a painful, extremely debilitating and potentially fatal inflammation of the colon associated with a bacterium called Clostridium difficile.  In the mid 1980s, Australian gastroenterologist, Professor Thomas Borody, who invented the triple antibiotic therapy for helicobacter pylori bacterium (the cause of stomach ulcers), was faced with one of the most difficult cases he had seen at that time.  His patient was a woman who had developed an in...