Fecal Microbiota Transplant and Its Evolving Medical Uses

TITLE: Fecal Microbiota Transplantation (FMT) in Multiple Sclerosis (MS) AUTHORS/INSTITUTIONS : T.J. Borody, S.M. Leis, J.L. Campbell, M. Torres, A. Nowak, , Centre for Digestive Diseases, Five Dock, New South Wales, AUSTRALIA; ABSTRACT BODY: Purpose: Recent evidence implicates the GI microbiota in the progression of neurological diseases such as Parkinsons Disease 1, Multiple Sclerosis and Myasthenia Gravis 2. We report three patients with MS diagnoses who achieved durable symptom reversal with FMT for constipation. Methods: Case study observations on three MS cases   Results: Case 1: A 30 yr old male with constipation, vertigo and impaired concentration and a concomitant history of MS and trigeminal neuralgia. Neurological symptoms included severe leg weakness and he required a wheelchair and an indwelling urinary catheter. Previous failed treatments included Mexiletine, Tryptanol and 9-interferon. The patient underwent 5 FMT i...

Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy   Borody TJ, Warren EF, Leis S, Surace R, Ashman O.   Source   Centre for Digestive Diseases, 144 Great North Rd, Five Dock NSW 2046, Australia.   Abstract   Background   Although the etiology of idiopathic ulcerative colitis (UC) remains poorly understood, the intestinal flora is suspected to play an important role. Specific, consistent abnormalities in flora composition peculiar to UC have not yet been described, however Clostridium difficile colitis has been cured by the infusion of human fecal flora into the colon. This approach may also be applicable to the treatment of UC on the basis of restoration of flora imbalances.   Goal     To observe the clinical, colonoscopic and histologic effects of human probiotic infusions (HPI) in 6 selected patients with UC.   Case Reports   Six patients (3 men and 3 women aged 25-53 years) with...

Professor Tom Borody, on ABC TV Australia, Catalyst, Thursday, 14 July 2011 talks about Fecal Microbiota Transplantation (FMT) also known as "human probiotic infusion" for treatment of clostridium difficlile (c-diff).  He is the pioneer and leading world expert on FMT. Please Click This Link To Leave A Comment!

In order to understand why a person would have a Fecal Microbiota Transplant, we first need to understand the incredible history of Fecal Microbiota Transplants. In 1958, Chief of Surgery at Denver General Hospital, Dr Ben Eiseman, reported in the Journal of Clinical Gastroenterology of four patients who were cured of pseudomembraneous colitis.  Enemas containing feces from healthy colons successfully replenished good digestive bacteria.  Pseudomenbranous is a painful, extremely debilitating and potentially fatal inflammation of the colon associated with a bacterium called Clostridium difficile.  In the mid 1980s, Australian gastroenterologist, Professor Thomas Borody, who invented the triple antibiotic therapy for helicobacter pylori bacterium (the cause of stomach ulcers), was faced with one of the most difficult cases he had seen at that time.  His patient was a woman who had developed an in...